JUBEREQ (denosumab-desu) 120 mg/1.7 mL injection, for subcutaneous use

JUBEREQ is an FDA-approved interchangeable biosimilar and offers identical dosing and administration as XGEVA.1,2

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JUBEREQ (denosumab-desu) 120 mg/1.7 mL injection, for subcutaneous use

JUBEREQ is an FDA-approved interchangeable biosimilar and offers identical dosing and administration as XGEVA.1,2

When ready to start or switch to JUBEREQ

See below for the coding and billing information you’ll need when JUBEREQ becomes commercially available.

CodingDescription
Q-Code: Q5166Injection, denosumab-desu (JUBEREQ), biosimilar, 1 mg
Administration CPT® Code: 96XXXDetermine appropriate product administration CPT code
JW/JZ ModifierJW Modifier: Drug amount discarded/not administered to any patient
OR
JZ Modifier: No discarded amounts
TB ModifierCMS requires all 340B-covered entities to report the TB modifier on claims
Billable UnitsDescription
1 milligram = 1 billing unitJUBEREQ dose = 120 milligrams
NDCDescription
69448-022-63 (10 digit)
69448-0022-63 (11 digit)
120 mg/1.7 mL (70 mg/mL) single-dose vial

CMS, Centers for Medicare & Medicaid Services; CPT, Current Procedural Terminology; NDC, National Drug Code.

Download Billing and Coding Guide

JUBEREQ has the same Medicare Part B* reimbursement as XGEVA.
Medicare Part B represents 33% of denosumabs with the same indications as JUBEREQ.3

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No step therapy edits

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No prior authorization needed

*Coverage and prior authorization requirements may vary by payer. This content is provided for informational purposes only. Accord BioPharma, Inc. does not guarantee coverage or reimbursement for JUBEREQ. It is the sole responsibility of healthcare professionals to ensure the reported codes are accurate, complete, and supported by medical record documentation.

JUBEREQ is covered on the following plans

Insurance PlanCoverage Type
MedicarePart B Fee-for-Service (FFS), effective 7/1/26
Cigna1-of-3 preferred on the Advantage, Performance, and Legacy Performance commercial pharmacy benefit drug lists, effective 7/1/26
Cigna1-of-3 preferred on the commercial medical benefit, effective 9/1/26

Coverage for JUBEREQ varies by insurance plan. Regarding the availability of JUBEREQ on your patient’s plan, please refer to their specific local insurance coverage policy requirements. We will update this website when new JUBEREQ coverage information is available.

Comprehensive support for the patient care journey

$0

co-pay per JUBEREQ treatment

For eligible patients

Co-Pay Program

Reduce out-of-pocket expenses

AccordCares® offers a co-pay program for eligible patients with commercial insurance that covers out-of-pocket expenses related to

Eligible patients may pay as little as $0 co-pay per JUBEREQ treatment.

Terms and Conditions may apply.

Co-pay program will be activated in July 2026, once JUBEREQ is available.

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Not an actual patient

register

Register your appropriate patients through AccordCares, and commercially insured eligible patients can start on JUBEREQ with a $0 co-pay.

patient-savings

Even if your practice has its own system for benefits reimbursement and prior authorizations, you can still use AccordCares to provide patients with a $0 co-pay.

Other key offerings include

Benefits Investigation

Benefits Investigation

Benefits Investigation

Prior Authorization Support

Billing and Coding Information

Billing and Coding Information

Alternate Funding Referral

Alternate Funding Referral

AccordCares Enrollment Form

For assistance, please call AccordCares at
1-866-258-7151.

Accord BioPharma

Accord BioPharma is a US-based company focused on biosimilars and specialty
pharmaceuticals that include oncology, immunology, and urology therapies.

20
by 2030

Global Biosimilar Leader

Accord’s parent company has more than 2 decades of experience, with products sold in 85+ countries.

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Accord is preparing a portfolio of
20 biosimilars by 2030.

fda-approved

Current portfolio of
7 FDA-approved therapies.

Accord has one of the largest biosimilar pipelines, with in oncology.

Accord has one of the largest biosimilar
pipelines, with 10 in oncology.

    Prepare your practice for JUBEREQ

    Connect with a JUBEREQ specialist today to prepare for July availability.

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    Important Safety Information

    Contraindications: JUBEREQ is contraindicated in patients with hypocalcemia. Pre-existing hypocalcemia must be corrected prior to initiating therapy. JUBEREQ is contraindicated in patients with known clinically significant hypersensitivity to denosumab products.

    Same Active Ingredient: Patients receiving JUBEREQ should not receive other denosumab products concomitantly.

    Hypersensitivity: Clinically significant hypersensitivity including anaphylaxis has been reported with denosumab products. Reactions may include hypotension, dyspnea, upper airway edema, lip swelling, rash, pruritus, and urticaria. If an anaphylactic or other clinically significant allergic reaction occurs, initiate appropriate therapy and discontinue JUBEREQ therapy permanently.

    Hypocalcemia: Severe symptomatic hypocalcemia and fatal cases have been reported. Correct pre-existing hypocalcemia prior to JUBEREQ treatment, and fatal cases have been reported. Monitor calcium levels throughout therapy, especially in the first weeks, and administer calcium, magnesium, and vitamin D as necessary. Concomitant use of calcimimetics and other drugs that can lower calcium levels may worsen hypocalcemia risk and serum calcium should be closely monitored. Advise patients to contact a healthcare provider for symptoms of hypocalcemia.

    Increased risk of hypocalcemia has been observed in patients with renal dysfunction, most commonly with severe dysfunction CrCl (<30 mL/min and/or on dialysis), and with inadequate/no calcium supplementation. Monitor calcium levels and calcium and vitamin D intake.

    Osteonecrosis of the Jaw (ONJ): ONJ has been reported manifesting as jaw pain, osteomyelitis, osteitis, bone erosion, tooth or periodontal infection, toothache, gingival ulceration, or gingival erosion. Persistent pain or slow healing of the mouth or jaw after dental surgery may also be manifestations of ONJ. In clinical trials the incidence of ONJ was higher with longer duration of exposure.

    Predisposing factors for developing ONJ include a history of tooth extraction, poor oral hygiene, and use of a dental appliance. Other risk factors include immunosuppressive therapy, use of angiogenesis inhibitors, systemic corticosteroids, diabetes, and gingival infections.

    Perform an oral examination and appropriate preventive dentistry prior to the initiation of JUBEREQ and periodically during therapy. Advise patients regarding oral hygiene practices. Avoid invasive dental procedures during treatment. Consider temporary discontinuation of JUBEREQ if an invasive dental procedure must be performed.

    Patients who are suspected of having or who develop ONJ while on JUBEREQ should receive care by a dentist or an oral surgeon. In these patients, extensive dental surgery to treat ONJ may exacerbate the condition.

    Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Atypical femoral fractures have been reported with denosumab products. These fractures can occur anywhere in the femoral shaft from just below the lesser trochanter to above the supracondylar flare and are transverse or short oblique in orientation without evidence of comminution.

    During JUBEREQ treatment, advise patients to report new or unusual thigh, hip, or groin pain. Any patient who presents with thigh or groin pain should be evaluated to rule out an incomplete femur fracture. Patients presenting with an atypical femur fracture should also be assessed for symptoms and signs of fracture in the contralateral limb. Interruption of JUBEREQ therapy should be considered, pending a risk/benefit assessment.

    Hypercalcemia Following Treatment Discontinuation in Patients with Giant Cell Tumor of Bone and in Patients with Growing Skeletons: Clinically significant hypercalcemia requiring hospitalization and complicated by acute renal injury has been reported in denosumab product-treated patients with giant cell tumor of bone and patients with growing skeletons within one year of treatment discontinuation. Monitor for signs and symptoms of hypercalcemia after treatment discontinuation and treat appropriately.

    Multiple Vertebral Fractures (MVF) Following Treatment Discontinuation: MVF have been reported following discontinuation of treatment with denosumab products. Patients at higher risk for MVF include those with risk factors for or a history of osteoporosis or prior fractures. When JUBEREQ treatment is discontinued, evaluate the patient’s risk for vertebral fractures.

    Embryo-Fetal Toxicity: JUBEREQ can cause fetal harm when administered to a pregnant woman. Based on data from animal studies and its mechanism of action, JUBEREQ is expected to result in adverse reproductive effects.

    Verify the pregnancy status of females of reproductive potential prior to the initiation of JUBEREQ. Advise pregnant women and females of reproductive potential that exposure to JUBEREQ during pregnancy or within 5 months prior to conception can result in fetal harm. Advise females of reproductive potential to use effective contraception during therapy, and for at least 5 months after the last dose of JUBEREQ.

    Most Common Adverse Reactions:

    • Bone Metastasis from Solid Tumors: Greater than or equal to 25%: fatigue/asthenia, hypophosphatemia, and nausea.
    • Multiple Myeloma: Greater than or equal to 10%: diarrhea, nausea, anemia, back pain, thrombocytopenia, peripheral edema, hypocalcemia, upper respiratory tract infection, rash, and headache.
    • Giant Cell Tumor of Bone: Greater than or equal to 10%: arthralgia, headache, nausea, back pain, fatigue, and pain in extremity.
    • Hypercalcemia of Malignancy: Greater than 20%: nausea, dyspnea, decreased appetite, headache, peripheral edema, vomiting, anemia, constipation, and diarrhea.

    INDICATIONS

    JUBEREQ is a RANK ligand (RANKL) inhibitor indicated for:

    • Prevention of skeletal-related events in patients with multiple myeloma and in patients with bone metastases from solid tumors.
    • Treatment of adults and skeletally mature adolescents with giant cell tumor of bone that is unresectable or where surgical resection is likely to result in severe morbidity.
    • Treatment of hypercalcemia of malignancy refractory to bisphosphonate therapy.

    To report SUSPECTED ADVERSE REACTIONS, contact Accord BioPharma Inc at 1-866-941-7875 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

    JUBEREQ (denosumab-desu) injection is supplied in a 120 mg/1.7 mL (70 mg/mL) single-dose vial.

    Click here for full Prescribing Information.

    XGEVA® (denosumab) is a registered trademark of Amgen Inc.

    References: 1. JUBEREQ (denosumab-desu) injection Prescribing Information. Accord BioPharma, Inc. 2. XGEVA (denosumab) Prescribing Information. Amgen Inc. 3. Data on file. Accord BioPharma, Inc.